Pure Nootropics’ Optimal Sleep Complex is formulated with ingredients to help support healthy sleep patterns by promoting sleep quality and duration and may reduce the amount of time it takes to fall asleep. Optimal Sleep Complex Plus encourages restful sleep and supports a refreshed mood when awakening.
Optimal Sleep Complex Benefits
- Magnesium Bisglycinate Chelate promotes longer sleep times and falling asleep faster (ref)*
- Zinc Bisglycinate Chelate promotes and regulates sleep quality (ref) *
- Lemon Balm and Valerian Root Combination supports sleep quality (ref)*
- L-Tryptophan may decrease the time it takes to fall asleep (ref)*
- L-Theanine promotes sleep quality (ref)*
- Melatonin may decrease time it takes to fall asleep (ref)*
- Magnesium Bisglycinate Chelate, Melatonin and Zinc Combination may improve sleep quality, sleep times, and support a refreshed mood when awakening (ref)(ref)*
Optimal Sleep Complex Mode of Action
Magnesium Bisglycinate Chelate is a mineral which helps promote longer sleep times and falling asleep faster through its ability to promote relaxation and calm the nervous system (2).
Zinc Bisglycinate Chelate is a trace element which promotes and regulates sleep quality, but the entirety of the mechanisms behind its actions with regards to sleep is still being researched (3).
Lemon Balm and Valerian Root Combination is a combination of the herbal extracts of Lemon Balm and Valerian root.
They are often used together because they exhibit synergy that may improve sleep quality. Lemon Balm acts as a GABA transaminase inhibitor; GABA is broken down into Glutamate by GABA transaminase, so the inhibition of this enzyme frees up more GABA in the brain. Valerian stimulates GABA by stimulating glutamate decarboxylase; glutamate is converted into GABA with this enzyme. The combination of Lemon Balm and Valerian is then able to stimulate the production of GABA within the brain by stimulating conversion of GABA and preventing the breakdown of GABA (4). Activation of GABA within the brain promotes sleep (5).
L-Tryptophan is an essential amino acid which is converted in the body into serotonin, which helps support healthy sleep patterns (6). This mechanism may decrease the time it takes to fall asleep (7).
L-Theanine is an amino acid which naturally occurs in tea leaves and some forms of mushrooms
(8).
L-Theanine promotes sleep quality due to its ability to provide relaxation by increasing alpha-brain waves and regulating excitatory neurotransmitters that may inhibit restful sleep. Alpha-brain waves (8-13 Hz) are the brain waves associated with relaxation and alertness and are produced within 30-40 minutes after ingestion. The alpha-brain waves (or “a-waves”) occur in the occipital and parietal regions of the brain and prepare the body for a relaxed state prior to sleep (9,10).
Melatonin is a hormone made in the human body within the pineal gland, retina, bone marrow cells, and gastrointestinal tract.
Melatonin regulates circadian rhythms and may decrease sleep latency (or the time it takes to fall asleep). Some research indicates that it reduces body temperature and that is mainly responsible for its ability to induce sleep. Melatonin decreases with age, especially between 41 and 60 years of age (11).
Optimal Sleep Complex Dosage
Pure Nootropics’ Optimal Sleep Complex was formulated based on researched and recommended dosages.
Pure Nootropics’ Optimal Sleep Complex provides 30 mg Magnesium Bisglycinate Chelate, 25 mg Zinc Bisglycinate Chelate, 400 mg L-Tryptophan, 400 mg Valerian root extract (standardized to 0.8% valerenic acid), 100 mg Lemon Balm extract, 100 mg L-Theanine, and 3 mg Melatonin per (2) capsules. Suggested use for adults is 1 capsule by mouth for light rest, or 2 capsules by mouth for deeper sleep, or as directed by your healthcare practitioner.
For further information, please see our References Tab above.
The references below are not meant to imply that any of our products treat, cure, or diagnose any disease or human condition. References to clinical studies and pre-clinical studies may use varying dosages and may not represent the dosages or subsequent results of products we sell; however, the references provided are pertinent to the subject supplement itself. References provided are intended for research and informational purposes only and do not represent the entire body of knowledge available on the subject(s) referenced; nor do they represent all possible outcomes associated with the subject(s) referenced including, but not limited to, adverse effects, precautions, or chemical interactions within the human body. The Content provided on this website is not intended to be a replacement for professional medical advice, treatment or diagnosis. Never ignore the advice of a medical professional or delay in attaining professional advice because of information or impressions you gather on this website. Choosing to rely on any information provided by the Content of this website is solely at your own risk. We encourage our audience to do their own research beyond the resources we have provided so your decision is as educated as possible.
• Magnesium Bisglycinate Chelate promotes longer sleep times and falling asleep faster*
Abbasi, Behnood et al. “The effect of magnesium supplementation on…elderly: A double-blind placebo-controlled clinical trial” Journal of research in medical sciences : the official journal of Isfahan University of Medical Sciences vol. 17,12 (2012): 1161-9.
• Zinc Bisglycinate Chelate promotes and regulates sleep quality*
Baradari, Afshin Gholipour, et al. “The Effect of Zinc Supplementation on Sleep Quality of ICU Nurses: A Double Blinded Randomized Controlled Trial.” Workplace Health & Safety, vol. 66, no. 4, Apr. 2018, pp. 191–200, doi:10.1177/2165079917734880.
• Lemon Balm and Valerian Root Combination supports sleep quality*
Cerny, A., and K. Schmid. “Tolerability and Efficacy of Valerian/Lemon Balm in Healthy Volunteers (a Double-Blind, Placebo-Controlled, Multicentre Study).” Fitoterapia, vol. 70, no. 3, 1 June 1999, pp. 221–228., doi.org/10.1016/S0367-326X(99)00018-0.
• L-Tryptophan may decrease time it takes to fall asleep*
Hartmann, E. “Effects of L-Tryptophan on Sleepiness and on Sleep.” J Psychiatr Res., vol. 17, no. 2, 1982, pp. 107–13., www.ncbi.nlm.nih.gov/pubmed/6764927.
• L-Theanine promotes sleep quality*
Rao, Theertham P., et al. “In Search of a Safe Natural Sleep Aid.” Journal of the American College of Nutrition, vol. 23, pp. 436–447., www.grc.com/health/research/Sleep/In Search of a Safe Natural Sleep Aid.pdf.
• Melatonin may decrease time it takes to fall asleep*
Auld, Fiona, et al. “Evidence for the Efficacy of Melatonin in the Treatment of Primary Adult Sleep…” Sleep Medicine Reviews, vol. 34, Aug. 2017, pp. 10–22., doi.org/10.1016/j.smrv.2016.06.005.
• Magnesium Bisglycinate Chelate, Melatonin and Zinc Combination may improve sleep quality, sleep times, and support a refreshed mood when awakening*
Rondanelli, M., et al. “The Effect of Melatonin, Magnesium, and Zinc…in Long-Term Care Facility Residents in Italy: a Double-Blind, Placebo-Controlled Clinical Trial.” J Am Geriatr Soc., vol. 59, no. 1, Jan. 2011, pp. 82–90., doi:doi: 10.1111/j.1532-5415.2010.03232.x.
“…Melatonin, Magnesium, and Zinc.” Am. Fam Physician, vol. 84, no. 11, Dec. 2011, p. 1293., www.aafp.org/afp/2011/1201/p1293.html.
1. “Magnesium,” Examine.com, published on 8 December 2013, last updated on 15 October 2018, https://examine.com/supplements/magnesium/.
2. Cook, Sarah. “Chelated Minerals: Addressing Key Challenges in Mineral Supplementation”.Natural Medicine Journal, 2018, https://www.naturalmedicinejournal.com/sites/default/files/uploads/chelated_minerals.pdf.
3. Cherasse, Yoan and Yoshihiro Urade. “Dietary Zinc Acts as a Sleep Modulator” International journal of molecular sciences vol. 18,11 2334. 5 Nov. 2017, doi:10.3390/ijms18112334.
4. “Melissa Officinalis,” Examine.com, published on 26 March 2013, last updated on 14 June 2018, https://examine.com/supplements/melissa-officinalis/.
5. Gottesmann, C. “GABA Mechanisms and Sleep.” Neuroscience, no. 111, ser. 2, 2002, pp. 231–9. 2, www.ncbi.nlm.nih.gov/pubmed/11983310.
6. Steriti, Ronald. “How To Get a Good Night’s Sleep with Tryptophan.” pdfs.semanticscholar.org/26ec/a60446a9a5e725f6e5f08c5ec3a195fffd31.pdf.
7. Hartmann, E. “Effects of L-Tryptophan on Sleepiness and on Sleep.” J Psychiatr Res., vol. 17, no. 2, 1982, pp. 107–13., www.ncbi.nlm.nih.gov/pubmed/6764927.
8. “Theanine.” Food, Herbs & Supplements, Professional. Natural Medicines, Therapeutic Research, naturalmedicines.therapeuticresearch.com/databases/food,-herbs-supplements/professional.aspx?productid=1053.
9. Rao, Theertham P., et al. “In Search of a Safe Natural Sleep Aid.” Journal of the American College of Nutrition, vol. 23, pp. 436–447., www.grc.com/health/research/Sleep/In Search of a Safe Natural Sleep Aid.pdf
10. Nobre, AC, et al. “L-Theanine, a Natural Constituent in Tea, and Its Effect on Mental State.” Asia Pac J Clin Nutr., vol. 17, no. 1, pp. 167–8., www.ncbi.nlm.nih.gov/pubmed/18296328.
11. “Melatonin,” Examine.com, published on 18 February 2014, last updated on 30 September 2018, https://examine.com/supplements/melatonin/.
12. “Melatonin.” Food, Herbs & Supplements, Professional. Natural Medicines, Therapeutic Research, https://naturalmedicines.therapeuticresearch.com/databases/food,-herbs-supplements/professional.aspx?productid=940#adverseEvents.
13. “Magnesium.” Food, Herbs & Supplements, Professional. Natural Medicines, Therapeutic Research, https://naturalmedicines.therapeuticresearch.com/databases/food,-herbs-supplements/professional.aspx?productid=998#toxicology.
14. “Zinc.” Food, Herbs & Supplements, Professional. Natural Medicines, Therapeutic Research, https://naturalmedicines.therapeuticresearch.com/databases/food,-herbs-supplements/professional.aspx?productid=982#adverseEvents.
14. “Valerian.” Drugs and Lactation Database (LactMed), 2006, www.ncbi.nlm.nih.gov/pubmed/30000874.
15. “Lemon Balm.” Drugs and Lactation Database (LactMed), 2006, www.ncbi.nlm.nih.gov/pubmed/30000874.
16. Institute of Medicine (2002). “Protein and Amino Acids”. Dietary Reference Intakes for Energy, Carbohydrates, Fiber, Fat, Fatty Acids, Cholesterol, Protein, and Amino Acids. Washington, DC: The National Academies Press. pp. 589–768.
17. “GRAS Notices.” U.S. Food & Drug Administration, www.accessdata.fda.gov/scripts/fdcc/index.cfm?set=GrASNotices&sort=Date_of_closure&order=ASC&showAll=true&type=basic&search=theanine.
18. Rondanelli, M., et al. “The Effect of Melatonin, Magnesium, and Zinc…in Long-Term Care Facility Residents in Italy: a Double-Blind, Placebo-Controlled Clinical Trial.” J Am Geriatr Soc., vol. 59, no. 1, Jan. 2011, pp. 82–90., doi: doi.org/10.1111/j.1532-5415.2010.03232.x.
19. “…Melatonin, Magnesium, and Zinc.” Am. Fam Physician, vol. 84, no. 11, Dec. 2011, p. 1293., www.aafp.org/afp/2011/1201/p1293.html.
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