CDP Choline, an abbreviation of cytidine-5′-diphosphocholine, referred to as Citicoline, is an essential nutrient and precursor for the neurotransmitter acetylcholine.
It is an efficient source of choline that supports overall brain function.
CDP Choline Benefits
- Supports cognitive function in the elderly (ref)*
- Attention Support (ref)(ref)*
- Provides support for cellular energy and mitochondrial health (ref)*
CDP Choline Description
CDP is one of our finest cholinergics. Cholinergics are a type of nootropic supplement that serves the primary function of increasing choline within the body so that your body can make a neurotransmitter called acetylcholine. Choline is an essential nutrient which we get from foods like eggs, certain types of meats, whole grains, and cruciferous vegetables. The body takes in the choline, and it becomes a building block for acetylcholine (5).
Acetylcholine helps neurons communicate with one another and is found in its highest amounts within the part of the brain that’s responsible for memory, learning, and attention (4).
Up to 92% of us aren’t getting enough choline from their diet alone, leaving the brain lacking what it needs to make one of the most important neurotransmitters! (4)
What does the Citicoline mean in CDP Choline?
The difference between our other cholinergics (or other products that are called “choline”) and our CDP Citicoline is that CDP Citicoline gives you an extra advantage. One of choline’s other functions is to help keep the membranes of cells healthy and intact so that unwanted pathogens and foreign material cannot break through the cellular membrane (4).
Maintaining healthy cell membranes is part of phospholipid synthesis; and in order for choline to assist with this role, it has to convert choline in the body into citicoline first (4).
Taking citicoline directly enables the body to skip this extra step and go straight towards improving cell barriers while providing essential choline at the same time (4).
CDP Choline helps you build a great foundation in your nootropic routine, either as a standalone product or part of a customized stack!
CDP Choline Dosage
Pure Nootropics’ CDP Choline Capsules provide 600 mg of Cognizin® Citicoline in each 2-capsule serving. Suggested use of CDP Choline capsules for adults is 2 capsules by mouth daily, or as directed by your healthcare practitioner.
For further information, please see our reference tab above.
The references below are not meant to imply that any of our products treat, cure, or diagnose any disease or human condition. References to clinical studies and pre-clinical studies may use varying dosages and may not represent the dosages or subsequent results of products we sell; however, the references provided are pertinent to the subject supplement itself. References provided are intended for research and informational purposes only and do not represent the entire body of knowledge available on the subject(s) referenced; nor do they represent all possible outcomes associated with the subject(s) referenced including, but not limited to, adverse effects, precautions, or chemical interactions within the human body. The Content provided on this website is not intended to be a replacement for professional medical advice, treatment or diagnosis. Never ignore the advice of a medical professional or delay in attaining professional advice because of information or impressions you gather on this website. Choosing to rely on any information provided by the Content of this website is solely at your own risk. We encourage our audience to do their own research beyond the resources we have provided so your decision is as educated as possible.
• Supports cognitive function in elderly*
Di Trapani, G, and M Fioravanti. “Citicoline in the Treatment of Cognitive and Behavioral Disorders in Pathologic Senile Decline.” Clin Ter, vol. 137, no. 6, 30 June 1991, pp. 403–13., www.ncbi.nlm.nih.gov/pubmed/1832612.
• May improve attentional performance*
McGlade, E, et al. “The Effect of Citicoline Supplementation on Motor Speed and Attention in Adolescent Males.” J Atten Disord, vol. 23, no. 2, Jan. 2019, pp. 121–134., doi:10.1177/1087054715593633. https://www.ncbi.nlm.nih.gov/pubmed/26179181.
McGlade, E, et al. “Improved Attentional Performance Following Citicoline Administration in Healthy Adult Women.” Food and Nutrition Sciences, no. 3, June 2012, pp. 769–773., doi:10.4236/fns.2012.36103. https://www.scirp.org/journal/paperinformation.aspx?paperid=19921.
• Promotes an increase in brain energy through improved mitochondrial function *
Cook, Sarah. “The Unique Benefits of CITICOLINE An Emerging Nootropic and Brain-Health Nutrient.” Natural Medicine Journal, 2018, www.naturalmedicinejournal.com/sites/default/files/uploads/citicoline.pdf.
5. Linus Pauling Institute. (2019). Choline. Web. https://lpi.oregonstate.edu/mic/other-nutrients/choline.
6. Alvarez, XA, et al. “Citicoline Improves Memory Performance in Elderly Subjects.” Methods Find Exp Clin Pharmacol, vol. 19, no. 3, Apr. 1997, pp. 201–10., www.ncbi.nlm.nih.gov/pubmed/9203170.
7. Leon-Carrion, J, et al. “The Role of Citicholine {sic} in Neuropsychological Training…” NeuroRehabilitation, vol. 14, no. 1, 2000, pp. 33–40., www.ncbi.nlm.nih.gov/pubmed/11455066.
8. Purves D, Augustine GJ, Fitzpatrick D, et al., editors. Neuroscience. 2nd edition. Sunderland (MA): Sinauer Associates; 2001. Glutamate. Available from: https://www.ncbi.nlm.nih.gov/books/NBK10807/.
9. Cooper GM. The Cell: A Molecular Approach. 2nd edition. Sunderland (MA): Sinauer Associates; 2000. Mitochondria. Available from: https://www.ncbi.nlm.nih.gov/books/NBK9896/.
10. Grieb, Pawel. “Neuroprotective properties of citicoline: facts, doubts and unresolved issues” CNS drugs vol. 28,3 (2014): 185-93. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3933742/.
11. Secades, JJ, and JL Lorenzo. “Citicoline: Pharmacological and Clinical Review, 2006 Update.” Methods Find Exp Clin Pharmacol, vol. 28, no. Suppl B, 2006, pp. 1–56., www.ncbi.nlm.nih.gov/pubmed/17171187.
12. “Citicoline”. Food, Herbs, & Supplements Professional. https://naturalmedicines.therapeuticresearch.com/databases/food,-herbs-supplements/professional.aspx?productid=1090#adverseEvents.
13. “Choline Fact Sheet for Health Professionals.” National Institutes of Health Office of Dietary Supplements, ods.od.nih.gov/factsheets/Choline-HealthProfessional/#h2.
14. “Uridine,” Examine.com, published on 2 October 2014, last updated on 14 June 2018, https://examine.com/supplements/uridine/.
15. “What source of choline should I use?,” Examine.com, published on 15 November 2013, last updated on 15 November 2013, https://examine.com/nutrition/what-source-of-choline-should-i-use/.
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