1-2-GO is a precise formula developed right here at Pure Nootropics. It showcases a combination of Caffeine and L-Theanine that supports focus and attention with an added lift from one of the smooth compounds you already know and love—Theobromine from chocolate!
Benefits
- (Caffeine + L-Theanine): Supports cognitive performance (ref)*
- (Caffeine + L-Theanine): Promotes benefits of caffeine without unwanted effects (ref)*
- (Caffeine + L-Theanine): Supports focus and attention (ref)*
- (Caffeine + L-Theanine): Promotes wakefulness and alertness (ref)*
- (Caffeine + L-Theanine): L-Theanine is General Recognized As Safe (GRAS) by U.S. FDA (ref)
- (Theobromine): A naturally occurring, mild stimulant responsible for the mood enhancing effects of chocolate (ref)*
1-2-GO Mode of Action
1-2-GO brings you cognitive benefits from the synergistic combination of Caffeine and L-Theanine. The L-theanine, a calming amino acid found in green tea, helps lessen many of the unwanted side effects associated with caffeine without losing caffeine’s legendary focus!
We added an extra boost of natural feel-good Theobromine (a mildly stimulating and pleasurable compound present in chocolate) to round out this formula. It’s part of the group of compounds known as methylxanthines, like caffeine, which act on adenosine receptors in the brain, but at only a tenth of caffeine’s strength. This little-known compound accounts for roughly 250 mg of a standard 40 g dark chocolate bar (7)(8)(9).
Caffeine and Theobromine are found together naturally in cocoa, cacao, and chocolate; while the combination of Caffeine, Theobromine and L-Theanine can be found in some teas (1).
The cognitive benefits associated with the Caffeine and L-Theanine combination were based on 50 mg caffeine to 100 mg L-Theanine. Our formula is based on a ratio of 1-part caffeine to 2 parts L-Theanine (6).
1-2-GO Dosage
Pure Nootropics’ 1-2-GO provides 390 mg of a proprietary blend of L-Theanine, Theobromine, and Caffeine per 1 capsule. Suggested use for adults is 1 capsule by mouth not more than every 4-6 hours, not to exceed more than 4 capsules in 24 hours.
1-2-GO Side Effects
This formula contains caffeine which is known to cause side effects and interactions with medications and some herbs. Please use responsibly and avoid if you are sensitive to caffeine. L-Theanine has GRAS status by the U.S. F.D.A. but may possibly reduce blood pressure and interactions could occur with some blood pressure medications, herbs, or other supplements. If you are taking any medications, herbs, or supplements, please consult your healthcare practitioner before beginning use of a supplement.
Please keep 1-2-GO out of the reach of curious pets. If accidental ingestion by a pet occurs, please seek veterinary attention immediately. Theobromine, as the ingredient in chocolate which makes chocolate harmful to pets, is very toxic to dogs because they metabolize it so slowly. While they can experience theobromine poisoning, humans can consume normal quantities of theobromine safely (13).
For further information, please see our References Tab above.
The references below are not meant to imply that any of our products treat, cure, or diagnose any disease or human condition References to clinical studies and pre-clinical studies may use varying dosages and may not represent the dosages or subsequent results of products we sell; however, the references provided are pertinent to the subject supplement itself. References provided are intended for research and informational purposes only and do not represent the entire body of knowledge available on the subject(s) referenced; nor do they represent all possible outcomes associated with the subject(s) referenced including, but not limited to, adverse effects, precautions, or chemical interactions within the human body. The Content provided on this website is not intended to be a replacement for professional medical advice, treatment or diagnosis. Never ignore the advice of a medical professional or delay in attaining professional advice because of information or impressions you gather on this website. Choosing to rely on any information provided by the Content of this website is solely at your own risk. We encourage our audience to do their own research beyond the resources we have provided so your decision is as educated as possible.
• Supports cognitive performance
Owen, GN, et al. “The Combined Effects of L-Theanine and Caffeine on Cognitive Performance and Mood.” Nutr Neurosci., vol. 11, no. 4, Aug. 2008, pp. 193–8., doi: doi:10.1179/147683008X301513.
• Promotes benefits of caffeine without unwanted effects
Dodd, FL, et al. “A Double-Blind, Placebo-Controlled Study Evaluating the Effects of Caffeine and L-Theanine Both Alone and in Combination on Cerebral Blood Flow, Cognition and Mood.” Pyschopharmacology (Berl), vol. 232, no. 14, July 2015, pp. 2563–76., doi:10.1007/s00213-015-3895-0.
• Supports focus and attention
Kahathuduwa, CN, et al. “l-Theanine and Caffeine Improve Target-Specific Attention to Visual Stimuli by Decreasing Mind Wandering: a Human Functional Magnetic Resonance Imaging Study.” Nutr Res., vol. 49, Jan. 2018, pp. 67–78., doi:10.1016/j.nutres.2017.11.002.
• Promotes wakefulness and alertness
Giesbrecht, T, et al. “The Combination of L-Theanine and Caffeine Improves Cognitive Performance and Increases Subjective Alertness.” Nut, vol. 13, no. 6, Dec. 2010, pp. 283–90., doi:10.1179/147683010X12611460764840.
• General Recognized as Safe (GRAS) by U.S. FDA
“GRAS Notices.” U.S. Food & Drug Administration, www.accessdata.fda.gov/scripts/fdcc/index.cfm?set=GrASNotices&sort=Date_of_closure&order=ASC&showAll=true&type=basic&search=theanine.
Theobromine Benefits
• A naturally occurring, mild stimulant responsible for the mood enhancing effects of chocolate
Baggott, Matthew J et al. “Psychopharmacology of theobromine in healthy volunteers.” Psychopharmacology vol. 228,1 (2013): 109-18. doi:10.1007/s00213-013-3021-0.
1. IARC Working Group on the Evaluation of Carcinogenic Risk to Humans. Coffee, Tea, Mate, Methylxanthines and Methylglyoxal. Lyon (FR): International Agency for Research on Cancer; 1991. (IARC Monographs on the Evaluation of Carcinogenic Risks to Humans, No. 51.) Theobromine. Available from: https://www.ncbi.nlm.nih.gov/books/NBK507032/.
2. “Caffeine”. Examine.com, published on Jul 26 2014, Last updated Mar 29, 2019. https://examine.com/supplements/caffeine/.
3. Giesbrecht, T, et al. “The Combination of L-Theanine and Caffeine Improves Cognitive Performance and Increases Subjective Alertness.” Nut, vol. 13, no. 6, Dec. 2010, pp. 283–90., doi:10.1179/147683010X12611460764840.
4. Dodd, FL, et al. “A Double-Blind, Placebo-Controlled Study Evaluating the Effects of Caffeine and L-Theanine Both Alone and in Combination on Cerebral Blood Flow, Cognition and Mood.” Pyschopharmacology (Berl), vol. 232, no. 14, July 2015, pp. 2563–76., doi:10.1007/s00213-015-3895-0.
5. Kahathuduwa, CN, et al. “l-Theanine and Caffeine Improve Target-Specific Attention to Visual Stimuli by Decreasing Mind Wandering: a Human Functional Magnetic Resonance Imaging Study.” Nutr Res., vol. 49, Jan. 2018, pp. 67–78., doi:10.1016/j.nutres.2017.11.002.
6. Owen, GN, et al. “The Combined Effects of L-Theanine and Caffeine on Cognitive Performance and Mood.” Nutr Neurosci., vol. 11, no. 4, Aug. 2008, pp. 193–8., doi:doi: 10.1179/147683008X301513.
7. “Where do cravings come from?” Examine.com, published Apr 17, 2017, Last updated Apr 18, 2017. https://examine.com/nutrition/where-do-cravings-come-from/.
8. Franco, R, et al. “Health Benefits of Methylxanthines in Cacao and Chocolate.” Nutrients., vol. 5, no. 10, 18 Oct. 2018, pp. 4159–73., doi:10.3390/nu5104159.
9. Baggott, Matthew J., et al. “Psychopharmacology of Theobromine in Healthy Volunteers.” Psychopharmacology, 31 Jan. 2013, doi:10.1007/s00213-013-3021-0.
10. “Theanine.” Food, Herbs & Supplements, Professional. Natural Medicines, Therapeutic Research, naturalmedicines.therapeuticresearch.com/databases/food,-herbs-supplements/professional.aspx?productid=1053.
11. “Caffeine.” Food, Herbs & Supplements, Professional. Natural Medicines, Therapeutic Research, https://naturalmedicines.therapeuticresearch.com/databases/food,-herbs-supplements/professional.aspx?productid=979#toxicology.
12. “3,7-Dimethylxanthine (Theobromine)”. Toxnet, US National Library of Medicine. 1 December 2017. Retrieved 13 November 2018.
13. “Theobromine.” Wikipedia, en.wikipedia.org/wiki/Theobromine#cite_ref-33.
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